Point Of Care Diagnostic Kit — Treponema pallidum Point-of-Care Diagnostic Kit Although the risk of syphilis spreading heterosexually has decreased in low and middle-income countries, it still remains a problem among some high-risk subpopulations. According to the World Health Organization’s report in 2012, there were 17.7 million syphilis cases among people aged 15 to 49 worldwide, with 5.6 million new cases annually. The Helix Biogen Institute has developed a diagnostic kit that utilizes bioinformatics in testing for Treponema pallidum. Onchocerciasis Diagnostic Kit River blindness, also known as onchocerciasis, is caused by a parasitic worm called Onchocerca volvulus. This worm is spread by infected black flies. Diagnosis of this disease is usually done through microscopic examination of skin biopsies. However, this method has its limitations. To improve diagnosis, Helix Biogen Institute has designed a synthetic protein using bioinformatics tools. This protein combines multiple immuno-dominant B-cell epitopes of different Onchocerca volvulus antigens. This new protein can help improve the accuracy and speed of diagnosis, particularly in regions where electricity is scarce. Schistosomiasis Diagnostic Kit Schistosomiasis is a deadly disease caused by a parasitic worm that is widespread in sub-Saharan African countries. It causes around 200,000 deaths every year globally, and has significantly increased morbidity and mortality rates. The current diagnostic techniques available have significant limitations in terms of their specificity. To improve the detection of schistosomiasis and reduce the prevalence of the disease in Africa, Helix Biogen Institute has developed a more accessible and simpler diagnostic kit using bioinformatics approaches. Loiasis Diagnostic Kit Loiasis is a parasitic disease that is prevalent in tropical regions of Africa and is transmitted by deerflies. Unfortunately, diagnosing the disease can be quite challenging as there are limited diagnostic tools available. As a result, it is crucial to develop biomarkers that can accurately and rapidly detect the presence of the Loa loa parasite in infected individuals. The application of bioinformatics and immunoinformatics pipelines can aid in the design of a highly precise diagnostic kit that can identify filarial antigens in the blood of infected individuals. Escherichia coli Point-of-care Diagnostic Kit Foodborne illnesses, also known as food poisoning, pose a significant public health threat and cause millions of illnesses, hospitalizations, and deaths each year. In response to the growing problem of chronic food poisoning caused by enterohemorrhagic E. coli, the Helix Biogen Institute conducted a study to develop a peptide-based diagnostic kit for the rapid detection of this pathogen in food. The kit is designed to make it easier and quicker to identify the bacteria present in infected foods. Point-of-care Diagnostic Kit for Detection of Cronobacter sakazakii in Powdered Infant Formula (PIF) The bacterium Cronobacter sakazakii has been found to contaminate powdered infant formula, leading to foodborne disease outbreaks. Since it is difficult to identify this organism in dietary substances, there is a need for a specific point-of-care diagnostic test. A multi-epitope point-of-care detection kit has been developed to easily detect Cronobacter sakazakii in powdered infant formula. Marburg Virus Peptide-Based Point-of-Care Diagnostic Kit The Marburg virus is a type of RNA virus that can lead to serious illness and has a high mortality rate. Although several methods have been developed to diagnose the disease, such as IgG-capture ELISA, RT-PCR, and antigen capture tests, they can be difficult to use on a large scale. A straightforward and dependable rapid point-of-care diagnostic kit is required to diagnose Marburg virus disease. In response, researchers have employed a computational approach to develop a point-of-care diagnostic kit that can identify viral antigens in a short period, allowing for quick and on-site diagnostic decisions. Plant-Based Antimicrobial Peptides The overuse of antibiotics has resulted in the development of drug-resistant bacteria, which poses a significant threat to human health. In light of this, antimicrobial peptides (AMPs) have emerged as a promising alternative to traditional antibiotics. AMPs have a high antimicrobial activity and offer several benefits over standard antibiotics, particularly in combating drug-resistant bacterial infections. The World Health Organization (WHO) has identified E. coli as a critical-priority microbe, and to tackle it, Helix Biogen Institute is currently using a computational and molecular docking approach to create plant-based antibacterial peptides.